Wooyoung Hur : rechercher sur Z-Library

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1

A Structure-Guided Approach to Creating Covalent FGFR Inhibitors

Wenjun Zhou, Wooyoung Hur, Ultan McDermott, Amit Dutt, Wa Xian, Scott B. Ficarro, Jianming Zhang, Sreenath V. Sharma, Joan Brugge, Matthew Meyerson, Jeffrey Settleman, Nathanael S. Gray

Journal:

Chemistry & Biology

Année:

2010

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2010

2

Synthesis and Target Identification of Hymenialdisine Analogs

Yongqin Wan, Wooyoung Hur, Charles Y. Cho, Yi Liu, Francisco J. Adrian, Olivier Lozach, Stéphane Bach, Thomas Mayer, Doriano Fabbro, Laurent Meijer, Nathanael S. Gray

Journal:

Chemistry & Biology

Année:

2004

Langue:

english

Fichier:

PDF, 302 KB

english, 2004

3

Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase

Wooyoung Hur, Anastasia Velentza, Sungjoon Kim, Laura Flatauer, Xinnong Jiang, David Valente, Daniel E. Mason, Melissa Suzuki, Brad Larson, Jianming Zhang, Anna Zagorska, Michael DiDonato, Advait Nagl

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 595 KB

english, 2008

4

Discovery and optimization of potent and selective benzonaphthyridinone analogs as small molecule mTOR inhibitors with improved mouse microsome stability

Qingsong Liu, Jinhua Wang, Seong A. Kang, Carson C. Thoreen, Wooyoung Hur, Hwan Geun Choi, David L. Waller, Taebo Sim, David M. Sabatini, Nathanael S. Gray

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 1.54 MB

english, 2011

5

Small molecule modulators of antioxidant response pathway

Wooyoung Hur, Nathanael S Gray

Journal:

Current Opinion in Chemical Biology

Année:

2011

Langue:

english

Fichier:

PDF, 352 KB

english, 2011

6

A Small-Molecule Inducer of the Antioxidant Response Element

Wooyoung Hur, Zheng Sun, Tao Jiang, Daniel E. Mason, Eric C. Peters, Donna D. Zhang, Hendrik Luesch, Peter G. Schultz, Nathanael S. Gray

Journal:

Chemistry & Biology

Année:

2010

Langue:

english

Fichier:

PDF, 1.52 MB

english, 2010

7

Allosteric inhibitors of Bcr-abl–dependent cell proliferation

Adrián, Francisco J, Ding, Qiang, Sim, Taebo, Velentza, Anastasia, Sloan, Christine, Liu, Yi, Zhang, Guobao, Hur, Wooyoung, Ding, Sheng, Manley, Paul

Journal:

Nature Chemical Biology

Année:

2006

Langue:

english

Fichier:

PDF, 386 KB

english, 2006

8

Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase

Sabine Hellwig, Chandra V. Miduturu, Shigeru Kanda, Jianming Zhang, Panagis Filippakopoulos, Eidarus Salah, Xianming Deng, Hwan Geun Choi, Wenjun Zhou, Wooyoung Hur, Stefan Knapp, Nathanael S. Gray, T

Journal:

Chemistry & Biology

Année:

2012

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2012

9

Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer

Liu, Feiyang, Zhang, Xin, Weisberg, Ellen, Chen, Sen, Hur, Wooyoung, Wu, Hong, Zhao, Zheng, Wang, Wenchao, Mao, Mao, Cai, Changmeng, Simon, Nicholas I., Sanda, Takaomi, Wang, Jinhua, Look, A. Thomas,

Journal:

ACS Chemical Biology

Année:

2013

Langue:

english

Fichier:

PDF, 856 KB

english, 2013

10

Discovery of EGFR Selective 4,6-Disubstituted Pyrimidines from a Combinatorial Kinase-Directed Heterocycle Library

Zhang, Qiong, Liu, Yi, Gao, Feng, Ding, Qiang, Cho, Charles, Hur, Wooyoung, Jin, Yunho, Uno, Tetsuo, Joazeiro, Claudio A. P., Gray, Nathanael

Journal:

Journal of the American Chemical Society

Année:

2006

Langue:

english

Fichier:

PDF, 92 KB

english, 2006

11

Discovery of 9-(6-Aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[ h ][1,6]naphthyridin-2(1 H )-one (Torin2) as a Potent, Selective, and Orally Available Mammalian Target of Rapamycin (mTOR) Inhibitor for Treatment of Cancer

Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Ahmed, Tausif, Sabatini, David M., Gray, Nathanael S.

Journal:

Journal of Medicinal Chemistry

Année:

2011

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2011

12

Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism

Xuan, Yi, Hur, Hoon, Ham, In-Hye, Yun, Jisoo, Lee, Ji-Yoon, Shim, Wooyoung, Kim, Young Bae, Lee, Gwang, Han, Sang-Uk, Cho, Yong Kwan

Journal:

Experimental Cell Research

Année:

2014

Langue:

english

Fichier:

PDF, 2.74 MB

english, 2014

13

Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in Saccharomyces cerevisiae

Liu, Qingsong, Ren, Tao, Fresques, Tara, Oppliger, Wolfgang, Niles, Brad J., Hur, Wooyoung, Sabatini, David M., Hall, Michael N., Powers, Ted, Gray, Nathanael S.

Journal:

ACS Chemical Biology

Année:

2012

Langue:

english

Fichier:

PDF, 2.44 MB

english, 2012

14

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1 H )-one as a Highly Potent, Selective Mammalian Target of Rapamycin (mTOR) Inhibitor for the Treatment of Cancer

Liu, Qingsong, Chang, Jae Won, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Markhard, Andrew, Hur, Wooyoung, Zhang, Jianming, Sim, Taebo, Sabatini, David M., Gray, Nathanael S.

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 2.22 MB

english, 2010

15

Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors

Tan, Li, Wang, Jun, Tanizaki, Junko, Huang, Zhifeng, Aref, Amir R., Rusan, Maria, Zhu, Su-Jie, Zhang, Yiyun, Ercan, Dalia, Liao, Rachel G., Capelletti, Marzia, Zhou, Wenjun, Hur, Wooyoung, Kim, NamDoo

Journal:

Proceedings of the National Academy of Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2014

16

A Discovery Strategy for Selective Inhibitors of c-Src in Complex with the Focal Adhesion Kinase SH3/SH2-binding Region

Moroco, Jamie A., Baumgartner, Matthew P., Rust, Heather L., Choi, Hwan Geun, Hur, Wooyoung, Gray, Nathanael S., Camacho, Carlos J., Smithgall, Thomas E.

Journal:

Chemical Biology & Drug Design

Année:

2015

Langue:

english

Fichier:

PDF, 1.55 MB

english, 2015

17

Identification of Novel ROS Inducers: Quinone Derivatives Tethered to Long Hydrocarbon Chains

Hong, Yeonsun, Sengupta, Sandip, Hur, Wooyoung, Sim, Taebo

Journal:

Journal of Medicinal Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 9.05 MB

english, 2015

18

Antimitotic Agents of Natural Origin

Nagle, Advait, Hur, Wooyoung, Gray, Nathanael

Journal:

Current Drug Targets

Année:

2006

Langue:

english

Fichier:

PDF, 231 KB

english, 2006

19

A benzo[b]thiophene-based selective type 4 S1P receptor agonist

Hur, Wooyoung, Rosen, Hugh, Gray, Nathanael S.

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2017

Langue:

english

Fichier:

PDF, 2.56 MB

english, 2017

20

Identification of the First Selective Activin Receptor-Like Kinase 1 Inhibitor, a Reversible Version of L-783277

Cho, Hanna, Sengupta, Sandip, Jeon, Sean S. H., Hur, Wooyoung, Choi, Hwan Geun, Seo, Hong-Seog, Lee, Byung Joo, Kim, Jeong Hun, Chung, Minhwan, Jeon, Noo Li, Kim, Nam Doo, Sim, Taebo

Journal:

Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 3.41 MB

english, 2017

21

Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion

Song, Chiman, Bae, Yeonju, Jun, JinJoo, Lee, Hyomin, Kim, Nam Doo, Lee, Kyung-Bok, Hur, Wooyoung, Park, Jae-Yong, Sim, Taebo

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Année:

2017

Langue:

english

Fichier:

PDF, 975 KB

english, 2017

22

Structure-activity relationship investigation for benzonaphthyridinone derivatives as novel potent Bruton's tyrosine kinase (BTK) irreversible inhibitors

Wang, Beilei, Deng, Yuanxin, Chen, Yongfei, Yu, Kailin, Wang, Aoli, Liang, Qianmao, Wang, Wei, Chen, Cheng, Wu, Hong, Hu, Chen, Miao, Weili, Hur, Wooyoung, Wang, Wenchao, Hu, Zhenquan, Weisberg, Ellen

Journal:

European Journal of Medicinal Chemistry

Année:

2017

Langue:

english

Fichier:

PDF, 3.99 MB

english, 2017

23

Amphiphilic small peptides for delivery of plasmid DNAs and siRNAs

Bang, Eun-Kyoung, Cho, Hanna, Jeon, Sean S-H, Tran, Na Ly, Lim, Dong-Kwon, Hur, Wooyoung, Sim, Taebo

Journal:

Chemical Biology & Drug Design

Année:

2017

Langue:

english

Fichier:

PDF, 825 KB

english, 2017

24

Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-β modulators

Elkamhawy, Ahmed, Kim, Nam youn, Hassan, Ahmed H.E., Park, Jung-eun, Yang, Jeong-Eun, Oh, Kwang-Seok, Lee, Byung Ho, Lee, Mi Young, Shin, Kye Jung, Lee, Kyung-Tae, Hur, Wooyoung, Roh, Eun Joo

Journal:

European Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 730 KB

english, 2018

25

First SAR study for overriding NRAS mutant driven acute myeloid leukemia

Cho, Hanna, Shin, Injae, Joo, Eunhye, choi, seunghye, Hur, Wooyoung, KIM, HAELEE, HONG, EUNMI, Kim, Nam Doo, Choi, Hwan Geun, Gray, Nathanael S, Sim, Taebo

Journal:

Journal of Medicinal Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 3.78 MB

english, 2018

26

Design, synthesis, and biological evaluation of novel aminopyrimidinylisoindolines as AXL kinase inhibitors

Choi, Min Jung, Roh, Eun Joo, Hur, Wooyoung, Lee, So Ha, Sim, Taebo, Oh, Chang-Hyun, Lee, Sun-Hwa, Kim, Jong Seung, Yoo, Kyung Ho

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2018

Langue:

english

Fichier:

PDF, 567 KB

english, 2018

27

Adaptive Linear Address Map for Bank Interleaving in DRAMs

Hur, Jae Young, Rhim, Sang Woo, Lee, Beom Hak, Jang, Wooyoung

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 2.27 MB

english, 2019

28

Identification of a Novel Oxadiazole Inhibitor of Mammalian Target of Rapamycin

Lim, Sunwoo, Lee, Hyomin, Kim, Euijung, Hur, Wooyoung

Journal:

Bulletin of the Korean Chemical Society

Année:

2020

Langue:

english

Fichier:

PDF, 1.26 MB

english, 2020